Despite genetic homogeneity, there remain heterogeneity in course of CML: it progresses at varying rates, from CP to AP and eventually to Blastic phase Strathdee G Holyoke TL, Sim A Parkr A, Osceir DG etal(2007) I, activation of HOXa gene by hypermethylation in Myeloid in lymhoid malignancy is frequent and associated with Poor prognosis Clin. Etiologically, CML is a homogeneous genetic disease, triggered by aberrant tyrosine kinase activity of BCR-ABL translocation. CML comprises about 15% of adult leukemias globally. DNA hypermethylation found in various types of leukemias including AML, ALL. Parallel Buses LVDS has traditionally been used as a standard for imple-menting parallel buses between chips on PCBs or for con-necting boards together with ribbon cables.
Anuradha Dey DCP(cal) MD(AIIMS)* Dr, Ranu Roy Biswas MD(cal) Asst Professor Pathology Dr Soma Das MBBS, DCH(cal) Demonstrator Pathology**** Surajit Sarkar Bsc(cal) DMLT(cal) *Dept of Pathology & microbiology Calcutta School of Tropical Medicine, C.R avenue Calcutta-73, W.B, India** 7/51 Purbapalli Sodepur 24 Parganas(north) Kol-110 W.B, India **** Dept of pathology, IPGME&R, Kolkata-20 W.B, India DNA methylation in promoter, CPG islands is mechanism of gene silencing, one of drivers of neoplastic transformation through inactivation of critical tumor-suppressor pathways. pare the operation and specifications of the LVDS and CML standards, and detail the methods for interfacing these two standards.
Bhattacharya **Rupak Bhattacharya BSc(cal),MSc(JU) **Ritwik Bhattacharya B.com(cal) **Soumyak Bhattacharya BHA ** Rupsa Bhattacharya of residence 7/51 Purbapalli, Sodepur, Kol-110 **Dalia Mukherjee BA(hons) cal, **Miss Oindrila Mukherjee, Debasis Mukherjee BSC(cl) of residence Swamijinagar, Habra *Dr. SML, which is also called a Characteristic Line, is a graphical representation of the market’s risk and. The CML is a line that is used to show the rates of return, which depends on risk-free rates of return and levels of risk for a specific portfolio. of Pathology Incharge DCP Course WBUHS *Miss Upasana Bhattacharya – daughter of Prof. CML stands for Capital Market Line, and SML stands for Security Market Line. of Pathology, In charge- DCP course WBUHS and Miss Upasana Bhattacharya Rupak Bhattacharya Ritwik Bhattacharya Soumyak Bhattacharya Rupsa Bhattacharya Dalia Mukherjee Oindrila Mukherjee Anuradha Dey Ranu Roy Biswas, Soma Das: Hriday Ranjan Das Surajit Sarkar Email corrosponding author -: Authors affiliation and Qualifications *Professor Pranab Kumar Bhattacharya MD(cal), FIC Path(Ind), Professor and Head, Dept. DNA Methylation in CML be partially reversed if treatment with decitabine and a combination of decitabine and Imatinib in CML & may show a promising response both in AP and BP of CML, Such drug combinations thus may be relevant even after therapy with second/third-generation Tyrosine kinase inhibitors Professor Pranab Kumar Bhattacharya MD(CAL) FICpath(Inda), Professor and Head, Dept.